[beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

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  • Additional Information
    • Publication Information:
      Wiley Subscription Services, Inc.
    • Publication Date:
      2018
    • Abstract:
      Byline: Ana P. Ames-Sibin, Camila L. Barizao, Cristiane V. Castro-Ghizoni, Francielli M. S. Silva, Anacharis B. Sa-Nakanishi, Livia Bracht,Ciomar A. Bersani-Amado,Maria R. Marcal-Natali,Adelar Bracht,Jurandir F. Comar Keywords: adjuvant-induced arthritis; copaiba oil; gluconeogenesis; liver metabolism; liver oxidative status; [beta]-caryophyllene Abstract The current study investigated the action of [beta]-caryophyllene, the major constituent of copaiba oil, on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. This study also compared the actions of [beta]-caryophyllene with those previously reported for copaiba oil on arthritic rats. For this purpose, Holtzman healthy and arthritic rats received 215 and 430mgaekg.sub.-1 [beta]-caryophyllene orally once a day during 18 days. Both doses of [beta]-caryophyllene reduced the adjuvant-induced paw edema, swollen of lymph nodes, and number of circulating and articular leukocytes. [beta]-Caryophyllene, at the dose of 430mgaekg .sub.-1, abolished the increases of protein carbonyl groups and myeloperoxidase activity in the liver and plasma of arthritic rats and, at both doses, it restored the increased levels of reactive oxygen species and reduced glutathione in the arthritic liver. These beneficial actions were of the same extension as those of copaiba oil ( Copaifera reticulata) and, therefore, [beta]-caryophyllene is possibly responsible for the anti-inflammatory and antioxidant actions of the oil. Hepatic gluconeogenesis was 40% lower in arthritic rats, which also presented a reduced number of hepatocytes per liver area (-23%) associated with increased hepatocyte area (+18%) and liver weight (+50%). None of these hepatic alterations were improved by [beta]-caryophyllene, but not even by ibuprofen. However, unlike copaiba oil, [beta]-caryophyllene did not modify the hepatic morphology and metabolism of healthy rats. These results reveal that [beta]-caryophyllene improves the systemic inflammation and oxidative status of arthritic rats and, in addition, it was not associated with hepatotoxicity.
    • ISSN:
      0730-2312
    • Accession Number:
      10.1002/jcb.27369
    • Rights:
      Copyright 2018 Gale, Cengage Learning. All rights reserved.
      COPYRIGHT 2018 Wiley Subscription Services, Inc.
    • Accession Number:
      edsgcl.561138707
  • Citations
    • ABNT:
      AMES-SIBIN, A. P. et al. [beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats. Journal of Cellular Biochemistry, [s. l.], n. 12, p. 10262, 2018. Disponível em: . Acesso em: 22 out. 2019.
    • AMA:
      Ames-Sibin AP, Barizao CL, Castro-Ghizoni CV, et al. [beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats. Journal of Cellular Biochemistry. 2018;(12):10262. doi:10.1002/jcb.27369.
    • APA:
      Ames-Sibin, A. P., Barizao, C. L., Castro-Ghizoni, C. V., Silva, F. M. S., Sa-Nakanishi, A. B., Bracht, L., … Comar, J. F. (2018). [beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats. Journal of Cellular Biochemistry, (12), 10262. https://doi.org/10.1002/jcb.27369
    • Chicago/Turabian: Author-Date:
      Ames-Sibin, Ana P., Camila L. Barizao, Cristiane V. Castro-Ghizoni, Francielli M. S. Silva, Anacharis B. Sa-Nakanishi, Livia Bracht, Ciomar A. Bersani-Amado, Maria R. Marcal-Natali, Adelar Bracht, and Jurandir F. Comar. 2018. “[Beta]-Caryophyllene, the Major Constituent of Copaiba Oil, Reduces Systemic Inflammation and Oxidative Stress in Arthritic Rats.” Journal of Cellular Biochemistry, no. 12: 10262. doi:10.1002/jcb.27369.
    • Harvard:
      Ames-Sibin, A. P. et al. (2018) ‘[beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats’, Journal of Cellular Biochemistry, (12), p. 10262. doi: 10.1002/jcb.27369.
    • Harvard: Australian:
      Ames-Sibin, AP, Barizao, CL, Castro-Ghizoni, CV, Silva, FMS, Sa-Nakanishi, AB, Bracht, L, Bersani-Amado, CA, Marcal-Natali, MR, Bracht, A & Comar, JF 2018, ‘[beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats’, Journal of Cellular Biochemistry, no. 12, p. 10262, viewed 22 October 2019, .
    • MLA:
      Ames-Sibin, Ana P., et al. “[Beta]-Caryophyllene, the Major Constituent of Copaiba Oil, Reduces Systemic Inflammation and Oxidative Stress in Arthritic Rats.” Journal of Cellular Biochemistry, no. 12, 2018, p. 10262. EBSCOhost, doi:10.1002/jcb.27369.
    • Chicago/Turabian: Humanities:
      Ames-Sibin, Ana P., Camila L. Barizao, Cristiane V. Castro-Ghizoni, Francielli M. S. Silva, Anacharis B. Sa-Nakanishi, Livia Bracht, Ciomar A. Bersani-Amado, Maria R. Marcal-Natali, Adelar Bracht, and Jurandir F. Comar. “[Beta]-Caryophyllene, the Major Constituent of Copaiba Oil, Reduces Systemic Inflammation and Oxidative Stress in Arthritic Rats.” Journal of Cellular Biochemistry, no. 12 (2018): 10262. doi:10.1002/jcb.27369.
    • Vancouver/ICMJE:
      Ames-Sibin AP, Barizao CL, Castro-Ghizoni CV, Silva FMS, Sa-Nakanishi AB, Bracht L, et al. [beta]-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats. Journal of Cellular Biochemistry [Internet]. 2018 [cited 2019 Oct 22];(12):10262. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgao&AN=edsgcl.561138707